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1

Structure-activity relationships of enkephalins containing serially replaced thiomethylene amide bond surrogates

Arno F. Spatola, Hossain Saneii, Judson V. Edwards, Anthony L. Bettag, Mohmed K. Anwer, Peter Rowell, Brian Browne, Robert Lahti, Philip Von Voigtlander

Journal:

Year:

1986

Language:

english

File:

PDF, 401 KB

english, 1986

2

A facile method for the direct synthesis of lanthionine containing cyclic peptides

Amit K. Galande, Arno F. Spatola

Journal:

International Journal of Peptide Research and Therapeutics

Year:

2001

Language:

english

File:

PDF, 405 KB

english, 2001

3

Synthesis of oxytocin and related diastereomers deuterated in the half-cystine positions. Comparison of solid-phase and solution methods

Spatola, Arno F., Cornelius, Dennis A., Hruby, Victor J., Blomquist, Alfred T.

Journal:

Journal of Organic Chemistry

Year:

1974

Language:

english

File:

PDF, 866 KB

english, 1974

4

Understanding base-assisted desulfurization using a variety of disulfide-bridged peptides

Amit K. Galande, John O. Trent, Arno F. Spatola

Journal:

Year:

2003

Language:

english

File:

PDF, 224 KB

english, 2003

5

Conformational comparison of cyclic peptide and pseudopeptide structures with intramolecular hydrogen bonding

Arno F. Spatola, Lila M. Gierasch, Arlene L. Rockwell

Journal:

Year:

1983

Language:

english

File:

PDF, 263 KB

english, 1983

6

Crystal structures of two cyclic pseudopentapeptides containing ψ[CH2S] and ψ[CH2SO] backbone surrogates

Sougen Ma, John F. Richardson, Arno F. Spatola

Journal:

Year:

1993

Language:

english

File:

PDF, 691 KB

english, 1993

7

Potent Inhibitors of LXXLL-Based Protein–Protein Interactions

Amit K. Galande, Kelli S. Bramlett, John O. Trent, Thomas P. Burris, James L. Wittliff, Arno F. Spatola

Journal:

Year:

2005

Language:

english

File:

PDF, 178 KB

english, 2005

8

ChemInform Abstract: Applications of CLEAR Resin for Solid Phase Organic Synthesis: Comparison with Polystyrene Based Resin

Krzysztof Darlak, Chatla Narayana, Arno F. Spatola

Journal:

Year:

2000

File:

PDF, 25 KB

2000

9

ChemInform Abstract: Head-to-Tail Cyclic Peptides and Cyclic Peptide Libraries

Arno F. Spatola, Peteris Romanovskis

Journal:

Year:

2000

File:

PDF, 24 KB

2000

10

Design and Synthesis of Cyclic Peptide Antagonists Intended to Block Coactivator Binding to Steroid Nuclear Receptors

Anne-Marie Leduc, Kelli S. Bramlett, Thomas P. Burris, Arno F. Spatola

Journal:

Year:

2003

File:

PDF, 4 KB

2003

11

By-Product Formation During SPPS of Linear, Cyclic, and Novel Bicyclic Peptides as AChE Inhibitors

Peteris Romanovskis, Terrone L. Rosenberry, Bernadette Cusack, Arno F. Spatola

Journal:

Year:

2003

File:

PDF, 59 KB

2003

12

Inhibition of mammalian collagenases by thiol-containing peptides

Robert D. Gray, Robert B. Miller, Arno F. Spatola

Journal:

Journal of Cellular Biochemistry

Year:

1986

Language:

english

File:

PDF, 422 KB

english, 1986

13

Assessment of biological activity of synthetic fragments of transforming growth factor-alpha

Krzysztof Darlak, Glen Franklin, Philip Woost, Elaine Sonnenfeld, Daniel Twardzik, Arno Spatola, Gregory Schultz

Journal:

Journal of Cellular Biochemistry

Year:

1988

Language:

english

File:

PDF, 629 KB

english, 1988

14

An approach to cyclic peptide libraries: Reducing epimerization in medium sized rings during solid phase synthesis

Arno F. Spatola, Krzysztof Darlak, Peteris Romanovskis

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 208 KB

english, 1996

15

Synthesis of a cyclic pseudopeptide containing a flexible β-Alaψ[CH2NH]unit

James Jun Wen, Arno F. Spatola

Journal:

Tetrahedron Letters

Year:

2005

Language:

english

File:

PDF, 118 KB

english, 2005

16

Improved detection limits in the analysis of tyrosine-containing polypeptide hormones by using electrochemical detection

Arno F. Spatola, Deanne E. Benovitz

Journal:

Journal of Chromatography A

Year:

1985

Language:

english

File:

PDF, 421 KB

english, 1985

17

Amide bond surrogates: pseudopeptides and macrocycles

Arno F. Spatola, Krzysztof Darlak

Journal:

Year:

1988

Language:

english

File:

PDF, 1000 KB

english, 1988

18

Cleavage of peptides bound to merrifield resins by potassium carbonate in the presence of a phase transfer reagent

Mohmed K. Anwer, Arno F. Spatola

Journal:

Tetrahedron Letters

Year:

1992

Language:

english

File:

PDF, 265 KB

english, 1992

19

Amino acids surrogates: an indirect method for the synthesis of peptides containing the thioasparaginyl residue

Hossain Saneii, Arno F. Spatola

Journal:

Tetrahedron Letters

Year:

1982

Language:

english

File:

PDF, 247 KB

english, 1982

20

Applications of ammonium formate catalytic transfer hydrogenolysis--IV1: a facile method for dehalogenation of aromatic chlorocarbons

Mohmed K. Anwer, Arno F. Spatola

Journal:

Tetrahedron Letters

Year:

1985

Language:

english

File:

PDF, 163 KB

english, 1985

21

A rapid non-acidolytic method for deprotection and removal of peptides from solid phase resins - applications of ammonium formate catalytic transfer hydrogenation

Mohmed K. Anwer, Arno F. Spatola

Journal:

Tetrahedron Letters

Year:

1981

Language:

english

File:

PDF, 227 KB

english, 1981

22

Synthesis of permethylated α-d-mannosylacetic acid, a new type of bioconjugate

Florence M. Brunel, K.Grant Taylor, Arno F. Spatola

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 86 KB

english, 2003

23

Solid phase synthesis of peptide hydroxamic acids

Jack J. Chen, Arno F. Spatola

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 225 KB

english, 1997

24

Synthesis and biological activities of ykfa analogues: effects of position 4 substitutions and altered ring size on In vitro opioid activity

John E Burden, Peg Davis, Frank Porreca, Arno F Spatola

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 97 KB

english, 2002

25

Synthesis and biological activities of position one and three transposed analogs of the opioid peptide YKFA

John E. Burden, Peg Davis, Frank Porreca, Arno F. Spatola

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 344 KB

english, 1999

26

Highly potent side chain–main chain cyclized dermorphin–deltorphin analogues: An integrated approach including synthesis, bioassays, NMR spectroscopy and molecular modelling

Seonggu Ro, Qin Zhu, Chang-Woo Lee, Murray Goodman, Krzysztof Darlak, Arno F. Spatola, Nga N. Chung, Peter W. Schiller, Annika B. Malmberg, Tony L. Yaksh, Thomas F. Burks

Journal:

Journal of Peptide Science

Year:

1995

Language:

english

File:

PDF, 1.52 MB

english, 1995

27

Using cyclic peptide mixtures as probes for metal ion host-guest interactions

Jian J. Chen, Lynn M. Teesch, Arno F. Spatola

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1996

Language:

english

File:

PDF, 526 KB

english, 1996

28

Synthesis and applications of alkylated C-sugars as peptide bioconjugates

Florence M. Brunel, Anne-Marie Leduc, Mark S. Mashuta, K. Grant Taylor, Arno F. Spatola

Journal:

International Journal of Peptide Research and Therapeutics

Year:

2002

Language:

english

File:

PDF, 464 KB

english, 2002

29

Tandem mass spectrometry for the structural determination of backbone-modified peptides

Leesa J. Deterding, Kenneth B. Tomer, Arno F. Spatola

Journal:

Journal of the American Society for Mass Spectrometry

Year:

1990

Language:

english

File:

PDF, 693 KB

english, 1990

30

A systematic approach to the solid-phase synthesis of linear and cyclic pseudopeptide libraries containing ψ[CH2NH] amide bond surrogates

JAMES J. WEN, ARNO F. SPATOLA

Journal:

Chemical Biology & Drug Design

Year:

1997

Language:

english

File:

PDF, 997 KB

english, 1997

31

Neutrophil rolling altered by inhibition of L-selectin shedding in vitro

Walcheck, Bruce, Kahn, Julius, Fisher, Joseph M., Wang, Bruce B., Fisk, R. Spencer, Payan, Donald G., Feehan, Carol, Betageri, Raj, Darlak, Krzystof, Spatola, Arno F.

Journal:

Year:

1996

File:

PDF, 1.04 MB

1996

32

Synthesis and characterization of cyclic pseudopeptide libraries containing thiomethylene and thiomethylene-sulfoxide amide bond surrogates

Yvon Crozet, James J. Wen, Rachel O. Loo, Philip C. Andrews, Arno F. Spatola

Journal:

Molecular Diversity

Year:

1997

Language:

english

File:

PDF, 161 KB

english, 1997

33

A facile method for the direct synthesis of lanthionine containing cyclic peptides

Amit K. Galande, Arno F. Spatola

Journal:

International Journal of Peptide Research and Therapeutics

Year:

2001

Language:

english

File:

PDF, 65 KB

english, 2001

34

DEUTERON MAGNETIC RESONANCE STUDIES OF NEUROHYPOPHYSIAL HORMONES

Jay A. Ghisel, Jeffrey F. McKelvy, Victor J. Hruby, Arno F. Spatola

Journal:

Annals of the New York Academy of Sciences

Year:

1973

Language:

english

File:

PDF, 734 KB

english, 1973

35

EQUILIBRIUM DIALYSIS STUDIES OF HORMONE-NEUROPHYSIN BINDING

Victor J. Hruby, Arno F. Spatola, Jay A. Glasel, Jeffrey F. McKelvy

Journal:

Annals of the New York Academy of Sciences

Year:

1975

Language:

english

File:

PDF, 345 KB

english, 1975

36

Applications of ammonium formate-catalytic transfer hydrogenation. : Part V (1). Transfer hydrogenolysis of peptides containing p-chlorophenylalanine as a convenient method for preparation of deuterium labeled peptides*

MOHMED K. ANWER, RICHARD A. PORTER, ARNO F. SPATOLA

Journal:

Chemical Biology & Drug Design

Year:

1987

Language:

english

File:

PDF, 570 KB

english, 1987

37

Backbone modifications in cyclic pep tides Conformational analysis of a cyclic pseudopentapeptide containing a thiomethylene ether amide bond replacement

MOHMED K. ANWER, DOUGLAS B. SHERMAN, ARNO F. SPATOLA

Journal:

Chemical Biology & Drug Design

Year:

1990

Language:

english

File:

PDF, 697 KB

english, 1990

38

Phase transfer catalysis in solid phase peptide synthesis : Preparation of cyclo[Xxx-Pro-Gly-Yyy-Pro-Gly] model peptides and their conformational analysis

ARNO F. SPATOLA, MOHMED K. ANWER, MEENA N. RAO

Journal:

Chemical Biology & Drug Design

Year:

1992

Language:

english

File:

PDF, 949 KB

english, 1992

39

Conformations of ψ[CH2NH] pseudopeptides : Cyclo[Gly-Proψ[CH2NH]Gly-D-Phe-Pro]-TFA and cyclo[Gly-Proψ[CH2NH] Gly-D-Phe-Pro]

SOUGEN MA, ARNO F. SPATOLA

Journal:

Chemical Biology & Drug Design

Year:

1993

Language:

english

File:

PDF, 302 KB

english, 1993

40

Amino monothio acids in solid-phase synthesis of peptide thioamides

THOMAS HOEG-JENSEN, ARNO F. SPATOLA, ARNE HOLM

Journal:

Chemical Biology & Drug Design

Year:

1996

Language:

english

File:

PDF, 981 KB

english, 1996

41

Evidence of a peptide backbone contribution toward selective receptor recognition for leucine enkephalin thioamide analogs

Kim Clausen, Arno F. Spatola, Carole Lemieux, Peter W. Schiller, Sven-Olov Lawesson

Journal:

Biochemical and Biophysical Research Communications

Year:

1984

Language:

english

File:

PDF, 322 KB

english, 1984

42

In vitro activity profiles of cyclic and linear enkephalin pseudopeptide analogs

Judson V. Edwards, Arno F. Spatola, Carole Lemieux, Peter W. Schiller

Journal:

Biochemical and Biophysical Research Communications

Year:

1986

Language:

english

File:

PDF, 415 KB

english, 1986

43

Biological activities of cyclic enkephalin pseudopeptides containing thioamides as amide bond replacements

Douglas B. Sherman, Arno F. Spatola, William S. Wire, Thomas F. Burks, T.M.-D. Nguyen, Peter W. Schiller

Journal:

Biochemical and Biophysical Research Communications

Year:

1989

Language:

english

File:

PDF, 450 KB

english, 1989

44

Biological activities of thionated thyrotropin-releasing hormone analogs

Leszek Lankiewicz, Cyril Y. Bowers, G.A. Reynolds, Virender Labroo, Louis A. Cohen, Stefan Vonhof, Anna-Leena Sirén, Arno F. Spatola

Journal:

Biochemical and Biophysical Research Communications

Year:

1992

Language:

english

File:

PDF, 618 KB

english, 1992

45

Modulation of acute inflammation by targeting glycosaminoglycan–cytokine interactions

James G. Cripps, Fabián A. Crespo, Peteris Romanovskis, Arno F. Spatola, Rafael Fernández-Botrán

Journal:

International Immunopharmacology

Year:

2005

Language:

english

File:

PDF, 260 KB

english, 2005

46

Synthesis and biological activity of a cyclic pseudohexapeptide analog of somatostatin

Thomas W. Gero, Arno F. Spatola, Ignacio Torres-Aleman, Andrew V. Schally

Journal:

Biochemical and Biophysical Research Communications

Year:

1984

Language:

english

File:

PDF, 253 KB

english, 1984

47

Dermorphin analogs: Resistance to in vitro enzymatic degradation is not always increased by additional D-amino acid substitutions

Krzysztof Darlak, Deanne E. Benovitz, Arno F. Spatola, Zbigniew Grzonka

Journal:

Biochemical and Biophysical Research Communications

Year:

1988

Language:

english

File:

PDF, 288 KB

english, 1988

48

Synthesis and biological activities of pseudopeptide analogues of LH-RH: Agonists and antagonists

Arno F. Spatola, Nirankar S. Agarwal, Anthony L. Bettag, John A. Yankeelov Jr., Cyril Y. Bowers, Wylie W. Vale

Journal:

Biochemical and Biophysical Research Communications

Year:

1980

Language:

english

File:

PDF, 504 KB

english, 1980

49

Metal binding peptide inhibitors of vertebrate collagenase

Robert D. Gray, Hossain H. Saneii, Arno F. Spatola

Journal:

Biochemical and Biophysical Research Communications

Year:

1981

Language:

english

File:

PDF, 1.23 MB

english, 1981

50

A highly potent antiovulatory LH-RH analogue with no 1-position side chain

Arno F. Spatola, Nirankar S. Agarwal

Journal:

Biochemical and Biophysical Research Communications

Year:

1980

Language:

english

File:

PDF, 176 KB

english, 1980